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Scientists aim to repair or replace p53 to combat cancer

Thu, 20 Feb 2025 09:40:58 GMT

Cancer arises when your cells grow uncontrollably and refuse to die when they should. Normally, your body is equipped with regulatory processes to prevent this chaos. One such mechanism involves a ...


Unlocking the Potential of PNC-27 Peptide in Cellular and Molecular Research

Thu, 06 Mar 2025 05:25:00 GMT

PNC-27 is a synthetic peptide composed of 32 amino acids. It is engineered to contain the MDM-2 binding domain of the tumor suppressor protein p53 fused with a membrane residency peptide. Its unique ...


ATM: the p53 booster

Tue, 25 Jun 2024 14:14:00 GMT

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.


The p53 and RB tumour-suppressor pathways

Thu, 08 Nov 2012 07:23:00 GMT

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...


Pulsed stimuli enable p53 phase resetting to synchronize single cells and modulate cell fate

Sun, 02 Mar 2025 16:00:00 GMT

Oscillatory p53 expression occurs in individual cells responding to DNA breaks. While the majority of cells exhibit the same qualitative response, quantitative features of the oscillations (e.g., ...


Carol Prives

Tue, 08 Oct 2024 13:09:00 GMT

Mutation of the p53 tumor suppressor gene is the most frequent lesion detected in cancer. Consequently, understanding the structure and function of the normal p53 protein and how it differs from the ...