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    Scientists aim to repair or replace p53 to combat cancer

     Wed, 19 Feb 2025 16:00:00 GMT
    One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

    p53 is both your genome’s guardian and weakness against cancer – scientists are trying to repair or replace it when it goes awry

     Thu, 20 Feb 2025 05:54:00 GMT
    Learning about how p53 works has not only deepened how scientists understand cancer, but also provided promising avenues for new treatments. In my work as a cancer researcher, I study the ...

    ATM: the p53 booster

     Tue, 25 Jun 2024 14:14:00 GMT
    The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

    The p53 and RB tumour-suppressor pathways

     Thu, 08 Nov 2012 07:23:00 GMT
    p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

    Researchers identify new p53 targets to combat cancer growth

     Sun, 23 Feb 2025 16:00:00 GMT
    Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

    Carol Prives

     Tue, 08 Oct 2024 13:09:00 GMT
    Mutation of the p53 tumor suppressor gene is the most frequent lesion detected in cancer. Consequently, understanding the structure and function of the normal p53 protein and how it differs from the ...