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    p53 : The Most Frequently Altered Gene in Human Cancers

     Sat, 25 Nov 2023 13:58:00 GMT
    p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

    ATM: the p53 booster

     Tue, 25 Jun 2024 14:14:00 GMT
    The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

    Frontier Medicines Announces FMC-220, the First Covalent p53 Y220C Activator Development Candidate, with Best-in-Class Potential

     Thu, 09 Jan 2025 05:01:00 GMT
    FMC-220 is a first-in-class covalent activator of p53Y220C designed to address potency and tolerability challenges of non-covalent approachesIn preclinical studies, FMC-220 demonstrated unprecedented ...