p53.html
p53 : The Most Frequently Altered Gene in Human Cancers
Sat, 25 Nov 2023 13:58:00 GMT
p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
How individual mutations of the tumor suppressor p53 affect pancreatic carcinomas
Wed, 04 Dec 2024 16:00:00 GMT
One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfill its task. Until now, researchers have assumed that the process is the same with all mutation types.
ATM: the p53 booster
Tue, 25 Jun 2024 14:14:00 GMT
The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.