p53.html
p53 : The Most Frequently Altered Gene in Human Cancers
Sat, 25 Nov 2023 13:58:00 GMT
p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
HTML5 Boilerplate
Sun, 22 Sep 2024 17:01:00 GMT
HTML5 Boilerplate est un modèle de projet open source pour la création de sites web rapides, robustes et adaptatifs. Il fournit une structure de base pour les sites web modernes avec des ...
Study reveals how mutant p53 protein converts other proteins into cancer drivers
Sun, 15 Sep 2024 17:00:00 GMT
The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...
The p53 and RB tumour-suppressor pathways
Thu, 08 Nov 2012 07:23:00 GMT
p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...
jantimon/html-webpack-plugin
Wed, 18 Jan 2023 09:38:00 GMT
The html-webpack-plugin works without configuration. It's a great addition to the ⚙️ webpack-config-plugins. If you have multiple webpack entry points, they will all be included with script tags in ...
tealeave/da-wei-lin-data
Fri, 20 May 2022 17:36:00 GMT
Tumor Suppressor Gene Reactivation: Developing novel approaches for directed drug design, especially in the development of small molecules to reactivate mutant p53 in human cancer. Proteomics & CRISPR ...
HTML5 Video Not Properly Encoded: What to Do
Sat, 15 Jun 2019 13:11:00 GMT
Struggling with various browser issues? Try a better option: Opera OneOver 300 million people use Opera One daily, a fully-fledged navigation experience coming with built-in packages, enhanced ...
Carol Prives
Tue, 08 Oct 2024 13:09:00 GMT
Mutation of the p53 tumor suppressor gene is the most frequent lesion detected in cancer. Consequently, understanding the structure and function of the normal p53 protein and how it differs from the ...
Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development
Mon, 23 Aug 2021 17:00:00 GMT
Impairment of centrosomal nucleation in apical progenitors of the developing mouse brain induces p53-dependent apoptosis and causes non-lethal microcephaly. Whether disruption of non-centrosomal ...
Lili Yamasaki
Thu, 15 Dec 2022 21:39:00 GMT
Previously, it has been shown that overexpression of E2F/DP transcriptional activity has vastly different effects on cells, in some settings leading to proliferation and in other cases leading to ...
Clasp Therapeutics to Present Preclinical Data Evaluating Novel T Cell Engager Targeting p53 Mutant Solid Tumors
Fri, 04 Oct 2024 06:38:00 GMT
Clasp Therapeutics, a biotechnology company bringing unparalleled precision to immuno-oncology using next-generation T cell engagers (TCEs), today announced it will present comprehensive preclinical ...
PMV Pharmaceuticals, Inc.
Sat, 06 May 2023 11:18:00 GMT
PMV Pharmaceuticals, Inc. is a precision oncology company, which engages in the discovery and development of small molecule, tumor-agnostic therapies targeting p53. The company was founded by ...