pdgfra
A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas
Fri, 08 Sep 2023 06:07:00 GMT
1 Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden 2 Department of Neuroscience, Neurology, Uppsala University, University Hospital, 751 85 Uppsala, ...
Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics
Sun, 24 Mar 2024 17:00:00 GMT
(A) tSNE plots showing cell distribution of the Pdgfra + dermal fibroblasts after re-clustering. (B) Bubble plots showing the expression of marker genes for each dFB cell cluster. Abbreviations: AP, ...
Development of 42 marker panel for in-depth study of cancer associated fibroblast niches in breast cancer using imaging mass cytometry
Sat, 20 Apr 2024 17:00:00 GMT
The final panel contained 6 CAF-associated markers (aSMA, FAP, PDGFRa, PDGFRb, YAP1, pSMAD2). Breast cancer tissues (4 cases of luminal, 5 cases of triple negative breast cancer) and a modified ...
Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
Tue, 05 Mar 2024 15:32:00 GMT
He was treated with high dose glucocorticoids and made a rapid recovery. Testing for FIP1L1-PDGFRA and other BCR-ABL1 mutations was negative. Ultimately, he was diagnosed with eosinophilic ...
DIPG in Children – What Can We Learn from the Past?
Mon, 19 Oct 2015 17:00:00 GMT
At the time of diagnosis, whenever available, biopsy specimens of DIPG are suggested to be tested for Histone K27M mutations (H3.3 and 3.1) along with routine WHO histological grading and other ...
Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification
Mon, 04 Mar 2024 16:00:00 GMT
Results indicate impaired myofibroblast proliferation, resulting in decreased cell number. InactzXivation of Etc2 in Pdgfra-lineaged cells, preventing cytokinesis of myofibroblasts, led to alveolar ...
A Study to Evaluate the Safety and Tolerability of DCC-2618 in Patients with Advanced Malignancies
Sat, 10 Feb 2018 11:43:00 GMT
Contact the study team to discuss study eligibility and potential participation. GIST patients must have a KIT or PDGFRA mutation and must have progressed on or had an intolerability to at least 1 ...
Prognostic model development and molecular subtypes identification in bladder urothelial cancer
Wed, 28 Feb 2024 13:59:00 GMT
As a result, a new risk signature was created that includes four genes associated with OS (RBPMS, CRYAB, P4HB, and PDGFRA). The researchers found two separate groups, C1 and C2, that showed ...
CCN1-Induced Cellular Senescence Promotes Heart Regeneration
Sun, 19 May 2019 17:00:00 GMT
School of Life Science and Technology, ShanghaiTech University, China (T.F., J.M., S.K., Z.J., X.H., Z.L., B.Z., H. Zhang). University of Chinese Academy of Sciences ...